Today's computer user is ad blind. But there are more content user than producer, there is still a gap. Computer users who are less computer savvy often do not know difference between your real website content and ads running on it. They are much likely to see ads on your website and click on them.
However, the population of data consumers is on Mobile. The ads running on your website should be compatible with mobile devices like a Smartphone or Tablet. Needless to say you should count much on running Responsive Ads in your website or blog.
If you are running many ads, try different permutations and combinations of ad formats like responsive ads, banner ads link ads etc. Keep watching your ad performance more often, take a note of which ad performing better in which place and keep changing till you reach a conclusion and set for it.